心血管、肾脏与代谢(CVRM)
改善和挽救数百万慢性粒细胞增多症患者的生命.
Home / 澳门葡京赌博游戏的治疗领域 /心血管、肾脏及代谢(CVRM)
澳门葡京赌博游戏致力于推进crvrm治疗
crvrm疾病对人的影响, 社会和澳门葡京赌博游戏的星球是巨大的和不断增长的, 然而，他们仍然没有得到充分的诊断, 未被充分对待，它们之间的联系也未被充分认识.1-7 These conditions affect hundreds of millions of people around the world; we estimate that one in three people with a CVRM disease are living with two or more of these chronic diseases.8
Our ambition is to enhance care to improve outcomes for the millions of people who are living with the complexities of CVRM diseases, 及早干预以保护重要器官, 减缓或阻止疾病进展, 并有一天甚至治愈这些经常使人衰弱的疾病, 进行性和危及生命的疾病.1
通过了解这些条件之间的相互联系, we’re able to extend the use of our existing medicines and build one of the world’s broadest, 最深和最强的crvrm管道.9 By 2032, 澳门葡京赌博游戏的目标是在crvrm治疗方面领先世界, 帮助改变医疗实践的过程和范围.
crvrm疾病未满足的需求和流行情况
亿
全球有60%的人患有慢性粒细胞白血病1
三分之一
crvrm患者存在以上两种或两种以上的症状8
98%
2型糖尿病患者至少有一种其他的crvrm疾病10
40%–50%
心力衰竭患者有慢性肾脏疾病11
Our R&D方法
Scientific research is advancing our understanding of how CVRM diseases are interconnected. We are investing in a portfolio of next-generation therapeutics which are addressing multiple risk factors and tackling the underlying drivers of disease across cardiorenal and cardiometabolic diseases to improve health outcomes.
通过结合前沿科学, 数字技术, 大数据和人工智能与人才的技能和经验, 澳门葡京赌博游戏的产品线超越了传统的小分子, 单克隆抗体和多肽, to include nucleotide modalities such as antisense oligonucleotides and small interfering RNA, 新的基因和 细胞疗法 有可能使重要器官再生.
同时, 澳门葡京赌博游戏正在与世界领先的学者合作, 非政府组织(NGOs), 生物技术和其他行业合作伙伴, 医疗专业人员, 患者和决策者改善检测和诊断, 简化临床试验, 扩大访问, 让澳门葡京赌博游戏的药物更快地惠及更多的人.
治疗慢性肾病
高频作用
仁慈的人工智能
As part of our approach to building knowledge from the masses of data to better understand disease biology, 澳门葡京赌博游戏和BenevolentAI合作过. 在这次合作中, 澳门葡京赌博游戏正在结合澳门葡京赌博游戏在疾病领域的专业知识和大型, diverse datasets with BenevolentAI’s leading artificial intelligence and machine learning capabilities to build knowledge graphs for HF, CKD, 特发性肺纤维化(IPF), 以及系统性红斑狼疮.
健康心脏非洲
Our 健康心脏非洲 programme is committed to tackling hypertension and the increasing burden of cardiovascular disease (CVD) in Africa. 自2014年在肯尼亚推出以来, 澳门葡京赌博游戏已经进行了超过1100万次血压检查, 检测到超过两百万的读数升高, 训练过5人以上,800名医护人员, 启动了700多家医疗机构. In support of the United Nations targets to reduce the risk of premature death from NCDs, 澳门葡京赌博游戏希望到2025年，整个非洲有1000万高血压患者.
为肾脏健康做出改变
为肾脏健康做出改变汇集了患者组织, medical experts and industry to call on governments and policymakers to recognise 慢性肾病 (CKD) as an urgent global health priority and implement patient-centred and evidence-based policies that enable earlier detection, 诊断和立即获得护理和推荐治疗. 通过这样做，澳门葡京赌博游戏的目标是为患者带来最好的结果, 卫生保健系统, 护理人员, 经济和地球. This campaign is co-created with the Global Patient Alliance for Kidney Health as well as funded and produced by 澳门葡京网赌游戏.
澳门葡京赌博游戏的人民
建立在一个令人印象深刻的遗产在crvrm, we are uniquely positioned to build a healthier and longer future for people with CVRM diseases. 澳门葡京赌博游戏超过1000人的团队跨越了23个功能，包括早期和晚期R&D，医疗和商业.
澳门葡京赌博游戏的员工都是有成就和经验丰富的科学家, 研究人员, 临床医生, and healthcare and commercial professionals dedicated to advancing novel science and driving practice change to benefit 病人 with CVRM diseases.
crvrm团队由以下人员领导:
加入澳门葡京赌博游戏的团队
澳门葡京赌博游戏的药品
We cannot provide detailed information about our prescription medicines on this website, 遵守规定. 澳门葡京赌博游戏的药品 are approved in individual countries for specific uses and the information we provide for 病人 is governed by local regulations. 在某些情况下, 医疗专业人员 and 病人 can visit local 澳门葡京网赌游戏 websites to find out more about our medicines. 请注意，在一些国家，澳门葡京赌博游戏不允许提供太多, 有时是任何, information on our prescription medicines so you should seek alternative trustworthy sources. 一定要向医疗保健专业人员咨询有关药物的建议.
澳门葡京赌博游戏的CVRM管道
With more than 25 therapies and therapy combinations in our early-to-late stage pipeline, we seek to bring real science and development to combatting life-threatening conditions. Our first-class scientific research today is setting the stage for our pioneering approach in the fields of disease regression and organ regeneration, 让澳门葡京赌博游戏离把科幻小说变成现实又近了一步.
第三阶段/LCM项目:指的是第二/第三阶段的关键资产, 或者已经提交监管部门批准的, and may include assets that are now launched in one or more major markets (removed when launched in all applicable major markets).
参考文献
1. Vos T，等. 204个国家和地区的369种疾病和伤害的全球负担, 1990-2019: 2019年全球疾病负担研究的系统分析. Lancet. 2020;396(10258):1204-22
2. Sarnak MJ，等. 慢性肾脏疾病和冠状动脉疾病:JACC最新进展综述. 我是科尔·卡迪诺. 2019;74(14):1823-38.
3. Tourki B，等. Heart Failure Syndrome With Preserved Ejection Fraction Is a Metabolic Cluster of Non-resolving Inflammation in Obesity. 前沿心血管医学. 2021;8:695952.
4. Rangaswami J，等. 心肾综合征:分类, 病理生理学, 诊断, 和治疗策略:美国心脏协会的科学声明. 循环. 2019;139(16):e840-e78.
5. Vogel B，等. The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030. Lancet. 2021;397(10292):2385-438.
6. Carpio E，等. Hypertension and cardiovascular risk factor management in a multi-ethnic cohort of adults with CKD: a cross sectional study in general practice. J Nephrol. 2022;35(3):901-10
7. Virani SS，等. Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association. 循环. 2020;141(9):e139-e596.
8. 澳门葡京网赌游戏数据存档. ref - 200649
9. 澳门葡京网赌游戏(互联网). 澳门葡京赌博游戏的管道. [引自2023年5月25日]. 可从:http://www获得.澳门葡京网赌游戏.com/our-therapy-areas/pipeline.html
10. Iglay K, Hannachi H, Joseph Howie P，等. Prevalence and co-prevalence of comorbidities among 病人 with type 2 diabetes mellitus. 当前医学研究意见. 2016年7月,32 (7):1243 - 52. doi:10.1185/03007995.2016.1168291
11. Vijay K等人. Heart Failure in Patients with Diabetes and Chronic Kidney Disease: Challenges and Opportunities. Cardiorenal地中海. (2022) 12 (1): 1–10.
Veeva ID: Z4-62672
筹备日期:2024年3月